نتایج جستجو برای: klf1 gene

تعداد نتایج: 1141436  

2012
Aurelie D. Desgardin Tatiana Abramova Tolulope O. Rosanwo Sreedharan Kartha Eun-Hee Shim Stephen M. Jane John M. Cunningham

Krüppel-like factor 1(KLF1) is a hematopoietic-specific zinc finger transcription factor essential for erythroid gene expression. In concert with the transacting factor GATA1, KLF1 modulates the coordinate expression of the genes encoding the multi-enzyme heme biosynthetic pathway during erythroid differentiation. To explore the mechanisms underpinning KLF1 action at the gene loci regulating th...

Journal: :Genome research 2010
Michael R Tallack Tom Whitington Wai Shan Yuen Elanor N Wainwright Janelle R Keys Brooke B Gardiner Ehsan Nourbakhsh Nicole Cloonan Sean M Grimmond Timothy L Bailey Andrew C Perkins

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse. We found at least 945 sites in the genome of E14.5 fetal liver erythroid cells which are occupied by endogenous KLF1. Many of these recovered s...

Journal: :Haematologica 2014
Divya S Vinjamur Kristen J Wade Safa F Mohamad Jack L Haar Stephen T Sawyer Joyce A Lloyd

The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins. Simultaneous ablation of KLF1 and KLF2 results in earlier embryonic lethality and severe anemia. In this study, we determine that this anemia is ca...

2016
Divya S. Vinjamur Yousef N. Alhashem Safa F. Mohamad Parth Amin David C. Williams Joyce A. Lloyd Andrew C. Wilber

In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-globin expression. In seeming contrast to the findings in adult cells, lower amounts of KLF1 correlate with both reduced embryonic and reduced...

Journal: :Haematologica 2012
Alice E Gallienne Hélène M P Dréau Anna Schuh John M Old Shirley Henderson

We investigated whether mutations in the KLF1 gene are associated with increased Hb F levels in ethnically diverse patients referred to our laboratory for hemoglobinopathy investigation. Functionally effective KLF1 mutations were identified in 11 out of 131 adult samples with an elevated Hb F level (1.5-25.0%). Eleven different mutations were identified, 9 of which were previously unreported. K...

Journal: :Blood 2015
Olga N Kuvardina Julia Herglotz Stephan Kolodziej Nicole Kohrs Stefanie Herkt Bartosch Wojcik Thomas Oellerich Jasmin Corso Kira Behrens Ashok Kumar Helge Hussong Henning Urlaub Joachim Koch Hubert Serve Halvard Bonig Carol Stocking Michael A Rieger Jörn Lausen

The activity of antagonizing transcription factors represents a mechanistic paradigm of bidirectional lineage-fate control during hematopoiesis. At the megakaryocytic/erythroid bifurcation, the cross-antagonism of krueppel-like factor 1 (KLF1) and friend leukemia integration 1 (FLI1) has such a decisive role. However, how this antagonism is resolved during lineage specification is poorly unders...

Journal: :Haematologica 2011
Stefania Satta Lucia Perseu Paolo Moi Isadora Asunis Annalisa Cabriolu Liliana Maccioni Franca Rosa Demartis Laura Manunza Antonio Cao Renzo Galanello

The persistence of high fetal hemoglobin level in adults may ameliorate the clinical phenotype of beta-thalassemia and sickle cell anemia. Several genetic variants responsible for hereditary persistence of fetal hemoglobin, linked and not linked to the beta globin gene cluster, have been identified in patients and in normal individuals. Monoallelic loss of KLF1, a gene with a key role in erythr...

Journal: :Blood 2013
Fatemehsadat Esteghamat Nynke Gillemans Ivan Bilic Emile van den Akker Ileana Cantù Teus van Gent Ursula Klingmüller Kirsten van Lom Marieke von Lindern Frank Grosveld Thamar Bryn van Dijk Meinrad Busslinger Sjaak Philipsen

B-cell lymphoma 11A (BCL11A) downregulation in human primary adult erythroid progenitors results in elevated expression of fetal γ-globin. Recent reports showed that BCL11A expression is activated by KLF1, leading to γ-globin repression. To study regulation of erythropoiesis and globin expression by KLF1 and BCL11A in an in vivo model, we used mice carrying a human β-globin locus transgene with...

2017
Melissa D. Ilsley Kevin R. Gillinder Graham W. Magor Stephen Huang Timothy L. Bailey Merlin Crossley Andrew C. Perkins

Krüppel-like factors (KLFs) are a family of 17 transcription factors characterized by a conserved DNA-binding domain of three zinc fingers and a variable N-terminal domain responsible for recruiting cofactors. KLFs have diverse functions in stem cell biology, embryo patterning, and tissue homoeostasis. KLF1 and related family members function as transcriptional activators via recruitment of co-...

Objective(s): β-thalassemia is one of the most common genetic disorders in the world. As one of the promising treatment strategies, fetal hemoglobin (Hb F) can be induced. The present study was an attempt to reactivate the γ-globin gene by introducing a gene construct containing KLF1 binding sites to the K562 cell line. Materials and Methods: A plasmid containing a 192 bp sequence with two repe...

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